MBD4

Across TCGA cell cohorts, MBD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,702 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MBD4-associated GO terms across cancer lineages are Double-strand break repair via nonhomologous end joining, Signal transduction in response to DNA damage, and Protein localization to chromosome. Each is linked with MBD4 in more than 13 cancer types. Because this analysis shows association rather than direction, both MBD4-to-partner and partner-to-MBD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via nonhomologous end joining grouped by MBD4-low versus MBD4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD4→partner) and Y-score (partner→MBD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Double-strand break repair via nonhomologous end joining →	+0.068	+0.925	.002	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Signal transduction in response to DNA damage →	+0.079	+0.598	<.001	.008	3	13
LUNG_NSCLC_LUSC	Protein localization to chromosome →	+0.100	+0.849	.002	<.001	3	13
LARGE_INTESTINE	Negative regulation of gene expression, epigenetic →	+0.068	+0.869	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.160	+0.626	<.001	.003	3	13
LARGE_INTESTINE	Protein sumoylation →	+0.072	+0.658	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,702 associations by consensus.

Double-strand break repair via nonhomologous end joining by MBD4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →