MBD4

Across TCGA cell cohorts, MBD4 mutation is significantly associated with the mutation status of many other genes, with 2,458 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBD4-associated genes across cancer lineages are IFT88, CELF2, and SLC35C2. Each is linked with MBD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MBD4-to-partner and partner-to-MBD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFT88 grouped by MBD4-low versus MBD4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD4→partner) and Y-score (partner→MBD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IFT88 →	+3.329	+3.799	.005	.005	1	3
LARGE_INTESTINE	CELF2 →	+3.329	+3.799	.005	.005	1	3
LARGE_INTESTINE	SLC35C2 →	+3.007	+3.584	.008	.008	1	3
LARGE_INTESTINE	SLC20A1 →	+3.007	+3.584	.008	.008	1	3
LARGE_INTESTINE	MARF1 →	+2.159	+3.807	.007	.007	1	3
LARGE_INTESTINE	IPO11 →	+2.574	+4.182	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,458 associations by consensus.

IFT88 by MBD4 expression — LARGE_INTESTINE

Explore this box plot interactively →