MBD3L5

Across TCGA patient cohorts, MBD3L5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD3L5-associated genes across cancer lineages are RNA5SP321, RNU6-198P, and RNU6ATAC2P. Each is linked with MBD3L5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD3L5-to-partner and partner-to-MBD3L5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP321 grouped by MBD3L5-low versus MBD3L5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD3L5→partner) and Y-score (partner→MBD3L5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP321 →	+1.008	+5.358	<.001	.006	3	1
UCEC	RNU6-198P →	+0.710	+5.358	<.001	.006	3	1
UCEC	RNU6ATAC2P →	+0.691	+5.081	<.001	.008	3	1
UCEC	IGHD6-19 →	+1.825	+5.420	<.001	.005	3	1
UCEC	MTND4P27 →	+0.120	+4.982	<.001	.009	3	1
UCEC	ATG4AP1 →	+0.200	+5.031	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

RNA5SP321 by MBD3L5 expression — UCEC

Explore this box plot interactively →