MBD3L3

Across TCGA pan-cancer cohorts, MBD3L3 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated MBD3L3 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher MBD3L3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MBD3L3 expression acts as an unfavorable survival marker, although some lineages such as PAAD show a favorable association.

BLCA, LUAD, and BRCA are the cancer types where MBD3L3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	III,IV	0.216	0.554	<.001	144	view →
LUAD	OS	Tertile	All	0.211	0.702	<.001	108	view →
BRCA	DFS	Tertile	All	0.140	1.000	.001	36	view →
CHOL	OS	Tertile	All	0.122	0.745	<.001	36	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
GBM	OS	Tertile	All	0.137	0.427	.004	18	view →
TGCT	DFS	Quartile	All	0.701	0.882	.025	12	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
PAAD	DFS	Tertile	All	1.000	0.241	.040	9	view →
SKCM	DFS	Tertile	III,IV	0.144	0.604	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

MBD3L3–BLCA (DFS)

Open the BLCA breakdown →