MBD3L2

Across TCGA pan-cancer cohorts, MBD3L2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MBD3L2 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher MBD3L2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MBD3L2 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

BLCA, THCA, and CESC are the cancer types where MBD3L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.124	0.457	.002	129	view →
THCA	DFS	Tertile	II,III,IV	0.137	0.773	.001	42	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	36	view →
KIRC	DFS	Tertile	IV	0.127	0.619	.008	36	view →
THYM	OS	Tertile	III,IV	0.212	1.000	.014	27	view →
LIHC	DFS	Tertile	II,III,IV	0.114	0.469	.010	27	view →
COAD	DFS	Tertile	All	0.449	0.784	.024	21	view →
GBM	OS	Tertile	All	0.132	0.417	.004	18	view →
SCLC	DFS	Tertile	All	0.192	0.793	.017	18	view →
MESO	OS	Tertile	II,III,IV	0.225	0.575	.023	18	view →
STAD	OS	Tertile	IV	0.052	0.541	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MBD3L2–BLCA (OS)

Open the BLCA breakdown →