MBD3

Across TCGA pan-cancer cohorts, MBD3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MBD3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MBD3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MBD3 is over-expressed in tumor.

COAD, LUAD, and HNSC are the cancer types where MBD3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MBD3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.639	<.001	12	view →
LUAD	Male	All	+0.397	<.001	9	view →
HNSC	Male	IV	+0.685	<.001	8	view →
LSCC	Male	All	+0.607	<.001	7	view →
PDAC	All	All	+0.240	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MBD3–COAD

Open the COAD breakdown →