MBD3

Across TCGA cell cohorts, MBD3 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MBD3-associated genes across cancer lineages are ANKRD30BL, MYH4, and TEX55. Each is linked with MBD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD3-to-partner and partner-to-MBD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD30BL grouped by MBD3-low versus MBD3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD3→partner) and Y-score (partner→MBD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ANKRD30BL →	+1.083	+3.874	<.001	.005	3	2
BLOOD_Leukemia	MYH4 →	+0.003	+4.384	<.001	.006	3	2
CNS	TEX55 →	+0.037	+4.321	<.001	.009	3	1
CNS	RNASE3 →	+0.063	+4.169	.002	.008	3	1
CNS	OR11H6 →	+0.016	+4.321	.001	.009	3	1
CNS	OR10G7 →	+0.010	+5.357	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ANKRD30BL by MBD3 expression — BLOOD_Leukemia

Explore this box plot interactively →