MBD1

Across TCGA patient cohorts, MBD1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD1-associated genes across cancer lineages are PDCD4, ATM, and cIAP. Each is linked with MBD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MBD1-to-partner and partner-to-MBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by MBD1-low versus MBD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD1→partner) and Y-score (partner→MBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.391	-1.797	.005	.003	3	3
UCEC	ATM →	-0.666	-1.807	<.001	<.001	3	3
COAD	cIAP →	+0.141	+2.820	.033	.035	3	2
COAD	Cyclin-E2 →	+0.315	+2.832	.008	.034	3	2
UCEC	eIF4E →	+0.173	+2.820	.006	.001	3	2
UCEC	ACC1 →	+0.331	+1.807	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

PDCD4 by MBD1 expression — UCEC

Explore this box plot interactively →