MBD1

Across TCGA cell cohorts, MBD1 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBD1-associated genes across cancer lineages are HAND1, BCO1, and UCN3. Each is linked with MBD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD1-to-partner and partner-to-MBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAND1 grouped by MBD1-low versus MBD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD1→partner) and Y-score (partner→MBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HAND1 →	+0.024	+3.408	<.001	.005	3	1
BLOOD_Leukemia	BCO1 →	+0.056	+3.409	.004	.008	3	1
BLOOD_Leukemia	UCN3 →	+0.017	+3.177	.001	.004	3	1
BLOOD_Leukemia	FAM47A →	+0.018	+3.507	<.001	.004	3	1
BLOOD_Leukemia	CYP2A13 →	+0.005	+4.247	<.001	.004	3	1
BLOOD_Leukemia	HIGD1C →	+0.087	+3.786	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

HAND1 by MBD1 expression — BLOOD_Leukemia

Explore this box plot interactively →