Across TCGA patient cohorts, MB mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MB-associated genes across cancer lineages are p70-S6K, Ku80, and Rictor_pT1135. Each is linked with MB in more than 1 cancer types. Because this analysis shows association rather than direction, both MB-to-partner and partner-to-MB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MB→partner) and Y-score (partner→MB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.258	+3.196	.014	.010	3	2
UCEC	Ku80 →	+0.396	+3.183	.002	.010	3	1
UCEC	Rictor_pT1135 →	-0.129	-3.169	.022	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.955	+2.827	.003	.035	3	1
UCEC	CD20 →	+0.174	+3.169	.015	.020	3	1
UCEC	VHL →	-1.219	-3.000	.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

MB survival (RNA) · tumor vs normal (RNA) · all MB data types