MAX

Across TCGA pan-cancer cohorts, MAX mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MAX’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MAX mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MAX is over-expressed in tumor.

COAD, LUAD, and LSCC are the cancer types where MAX tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAX mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.255	<.001	10	view →
LUAD	Female	III,IV	+0.375	<.001	9	view →
LSCC	All	II,III,IV	+0.326	<.001	8	view →
HNSC	Male	II,III,IV	+0.263	<.001	8	view →
PDAC	Female	All	+0.375	.001	3	view →
CCRCC	Male	All	+0.130	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

MAX–COAD

Open the COAD breakdown →