MAU2

Across TCGA patient cohorts, MAU2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAU2-associated genes across cancer lineages are Lck, Caspase-7-cleavedD198, and PREX1. Each is linked with MAU2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAU2-to-partner and partner-to-MAU2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by MAU2-low versus MAU2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAU2→partner) and Y-score (partner→MAU2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.291	+2.115	<.001	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+1.036	+3.604	<.001	.001	3	2
COAD	PREX1 →	+0.258	+3.025	.016	.019	3	1
UCEC	EGFR_pY1068 →	-0.271	-3.584	.013	.002	3	1
UCEC	eIF4E →	+0.181	+2.115	.049	.019	3	1
UCEC	IGFBP2 →	-0.629	-3.000	.026	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Lck by MAU2 expression — UCEC

Explore this box plot interactively →