MATR3

Across TCGA patient cohorts, MATR3 mutation is significantly associated with the RNA expression of many other genes, with 4,128 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MATR3-associated genes across cancer lineages are LETM1, CDCA2, and C1orf174. Each is linked with MATR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both MATR3-to-partner and partner-to-MATR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LETM1 grouped by MATR3-low versus MATR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATR3→partner) and Y-score (partner→MATR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LETM1 →	+0.436	+1.960	<.001	<.001	3	4
COAD	CDCA2 →	+0.871	+3.598	<.001	.001	3	3
UCEC	C1orf174 →	+0.383	+2.435	<.001	<.001	3	3
COAD	ADCY6-DT →	+0.821	+3.584	.001	.002	3	3
SKCM	FEN1 →	+0.717	+3.465	.001	.003	3	3
SKCM	COX5A →	+0.449	+3.340	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,128 associations by consensus.

LETM1 by MATR3 expression — UCEC

Explore this box plot interactively →