MATN4

Across TCGA pan-cancer cohorts, MATN4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MATN4 data layer compared with 18 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MATN4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MATN4 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, GBM, and LSCC are the cancer types where MATN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.342	0.879	<.001	69	view →
GBM	DFS	Tertile	All	0.757	0.223	.001	16	view →
LSCC	DFS	Quartile	All	0.156	1.000	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MATN4–HNSC (DFS)

Open the HNSC breakdown →