MATN4

Across TCGA patient cohorts, MATN4 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MATN4-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and PI3K-p85. Each is linked with MATN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MATN4-to-partner and partner-to-MATN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MATN4-low versus MATN4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATN4→partner) and Y-score (partner→MATN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.431	+2.815	<.001	.036	3	3
UCEC	eIF4E →	+0.216	+2.807	.019	.003	3	3
SKCM	PI3K-p85 →	+0.193	+1.749	.019	.049	3	2
SKCM	PRDX1 →	+0.270	+2.321	.018	.032	3	2
SKCM	Smad1 →	-0.155	-2.502	.005	.001	3	2
UCEC	MSH2 →	-0.379	-2.295	<.001	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by MATN4 expression — COAD

Explore this box plot interactively →