MATN3

Across TCGA pan-cancer cohorts, MATN3 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated MATN3 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MATN3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MATN3 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

COAD and SKCM are the cancer types where MATN3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.461	0.787	.018	12	view →
SKCM	DFS	Median	III,IV	1.000	0.249	.032	5	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

MATN3–COAD (OS)

Open the COAD breakdown →