MATN3

Across TCGA patient cohorts, MATN3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MATN3-associated genes across cancer lineages are MSH6, EGFR_pY1068, and JNK2. Each is linked with MATN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MATN3-to-partner and partner-to-MATN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by MATN3-low versus MATN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATN3→partner) and Y-score (partner→MATN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.514	-2.999	.001	.035	3	2
UCEC	EGFR_pY1068 →	-0.255	-2.459	.035	.020	3	1
UCEC	JNK2 →	+0.293	+2.817	.002	.036	3	1
UCEC	MSH2 →	-0.445	-3.312	<.001	.010	3	1
UCEC	p70-S6K →	+0.232	+2.486	.012	.011	3	1
UCEC	PCNA →	+0.301	+2.459	.003	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MSH6 by MATN3 expression — UCEC

Explore this box plot interactively →