MATN3

Across TCGA cell cohorts, MATN3 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible MATN3-associated genes across cancer lineages are OR2L8, CFHR2, and NOBOX. Each is linked with MATN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MATN3-to-partner and partner-to-MATN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by MATN3-low versus MATN3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATN3→partner) and Y-score (partner→MATN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L8 →	+0.015	+5.266	<.001	.001	3	2
SKIN	CFHR2 →	+0.047	+4.977	<.001	.007	3	2
LUNG_NSCLC_LUSC	NOBOX →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PF4V1 →	+0.296	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	FSHB →	+0.016	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	LCN9 →	+0.036	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

OR2L8 by MATN3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →