MATN2

Across TCGA patient cohorts, MATN2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MATN2-associated genes across cancer lineages are HER3_pY1289, Annexin-1, and A-Raf_pS299. Each is linked with MATN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MATN2-to-partner and partner-to-MATN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by MATN2-low versus MATN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATN2→partner) and Y-score (partner→MATN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.055	+1.152	.034	.021	3	3
UCEC	Annexin-1 →	+0.484	+1.682	.002	.006	3	3
LUSC	A-Raf_pS299 →	+0.292	+2.816	.033	.036	3	2
UCEC	FoxM1 →	+0.225	+1.754	.004	.001	3	2
UCEC	INPP4B →	-0.356	-2.736	<.001	<.001	3	2
UCEC	JNK2 →	+0.280	+2.257	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

HER3_pY1289 by MATN2 expression — UCEC

Explore this box plot interactively →