MATN2

Across TCGA cell cohorts, MATN2 mutation is significantly associated with the RNA expression of many other genes, with 313 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MATN2-associated genes across cancer lineages are C12orf65, COL11A2, and ADAM7. Each is linked with MATN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MATN2-to-partner and partner-to-MATN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf65 grouped by MATN2-low versus MATN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATN2→partner) and Y-score (partner→MATN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C12orf65 →	+0.449	+3.364	.003	.002	3	2
LARGE_INTESTINE	COL11A2 →	+0.564	+3.131	.001	.008	3	2
SKIN	ADAM7 →	+0.009	+3.684	<.001	.006	3	2
SKIN	OR13D1 →	+0.030	+3.930	<.001	.003	3	2
SKIN	OR6A2 →	+0.054	+3.758	<.001	.007	3	2
OESOPHAGUS	APOC4 →	+0.104	+4.017	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 313 associations by consensus.

C12orf65 by MATN2 expression — LARGE_INTESTINE

Explore this box plot interactively →