MATN1

Across TCGA pan-cancer cohorts, MATN1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MATN1 data layer compared with 23 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MATN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MATN1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

KIRP, BLCA, and TGCT are the cancer types where MATN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.272	0.885	<.001	12	view →
BLCA	OS	Median	II,III,IV	1.000	0.411	.045	8	view →
TGCT	DFS	Median	All	0.082	0.837	<.001	6	view →
SKCM	DFS	Median	III,IV	0.141	0.615	.005	6	view →
UCEC	DFS	Median	II,III,IV	0.922	0.441	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MATN1–KIRP (OS)

Open the KIRP breakdown →