MATK

Across TCGA patient cohorts, MATK mutation is significantly associated with the RNA expression of many other genes, with 2,897 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MATK-associated genes across cancer lineages are WDR5, HNRNPCP1, and RFC5. Each is linked with MATK in more than 2 cancer types. Because this analysis shows association rather than direction, both MATK-to-partner and partner-to-MATK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR5 grouped by MATK-low versus MATK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATK→partner) and Y-score (partner→MATK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR5 →	+0.465	+2.447	.003	.001	3	3
UCEC	HNRNPCP1 →	+0.666	+2.947	<.001	<.001	3	3
UCEC	RFC5 →	+0.574	+2.593	.001	.006	3	3
UCEC	NCAPH2 →	+0.477	+3.716	.002	<.001	3	3
SKCM	DCTN3 →	+0.367	+2.006	.002	.005	3	3
SKCM	UBXN11 →	+0.438	+2.710	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,897 associations by consensus.

WDR5 by MATK expression — UCEC

Explore this box plot interactively →