MATK

Across TCGA patient cohorts, MATK mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MATK-associated genes across cancer lineages are eIF4E, ERK2, and mTOR_pS2448. Each is linked with MATK in more than 1 cancer types. Because this analysis shows association rather than direction, both MATK-to-partner and partner-to-MATK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MATK-low versus MATK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATK→partner) and Y-score (partner→MATK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.226	+3.013	.017	.018	3	2
UCEC	ERK2 →	+0.216	+2.700	.012	.006	3	2
UCEC	mTOR_pS2448 →	-0.220	-3.439	.001	.005	3	2
UCEC	Notch1 →	+0.216	+3.469	<.001	.002	3	2
UCEC	TIGAR →	+0.146	+2.727	.034	.003	3	2
UCEC	EGFR_pY1068 →	-0.242	-2.000	.032	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by MATK expression — UCEC

Explore this box plot interactively →