MATK

Across TCGA cell cohorts, MATK mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MATK-associated genes across cancer lineages are LRRC74A, PRAMEF25, and PCDH11Y. Each is linked with MATK in more than 1 cancer types. Because this analysis shows association rather than direction, both MATK-to-partner and partner-to-MATK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC74A grouped by MATK-low versus MATK-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATK→partner) and Y-score (partner→MATK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LRRC74A →	+0.013	+4.807	<.001	.006	3	1
URINARY_TRACT	PRAMEF25 →	+0.013	+5.087	<.001	.004	3	1
URINARY_TRACT	PCDH11Y →	+0.016	+5.087	<.001	.004	3	1
BLOOD_Leukemia	TTLL2 →	+0.386	+3.736	<.001	.005	3	1
BLOOD_Leukemia	C20orf85 →	+0.015	+3.969	.005	.009	3	1
BLOOD_Leukemia	PAX1 →	+0.045	+3.475	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

LRRC74A by MATK expression — BLOOD_Myeloma

Explore this box plot interactively →