MAT1A

Across TCGA pan-cancer cohorts, MAT1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MAT1A data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MAT1A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MAT1A expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

CCRCC, GBM, and HNSC are the cancer types where MAT1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.109	0.731	.012	14	view →
GBM	DFS	Tertile	All	0.873	0.238	.024	5	view →
HNSC	DFS	Quartile	III,IV	0.554	0.946	.023	2	view →
LUAD	DFS	Median	All	0.457	0.744	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MAT1A–CCRCC (OS)

Open the CCRCC breakdown →