MAT1A

Across TCGA pan-cancer cohorts, MAT1A mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MAT1A’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where MAT1A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MAT1A is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

PDAC, LSCC, and CCRCC are the cancer types where MAT1A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAT1A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−2.155	<.001	8	view →
LSCC	All	All	+0.498	<.001	6	view →
CCRCC	All	II,III,IV	+0.423	.025	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

MAT1A–PDAC

Open the PDAC breakdown →