MAT1A

Across TCGA patient cohorts, MAT1A mutation is significantly associated with the RNA expression of many other genes, with 3,863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAT1A-associated genes across cancer lineages are CENPU, WDHD1, and DONSON. Each is linked with MAT1A in more than 3 cancer types. Because this analysis shows association rather than direction, both MAT1A-to-partner and partner-to-MAT1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by MAT1A-low versus MAT1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAT1A→partner) and Y-score (partner→MAT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.623	+1.809	<.001	.001	3	4
UCEC	WDHD1 →	+0.726	+4.108	<.001	<.001	3	4
UCEC	DONSON →	+0.544	+4.119	<.001	<.001	3	3
UCEC	POC1A →	+0.537	+2.823	.001	<.001	3	3
UCEC	SFXN1 →	+0.547	+2.058	<.001	<.001	3	3
UCEC	ENTR1 →	+0.466	+2.101	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,863 associations by consensus.

CENPU by MAT1A expression — UCEC

Explore this box plot interactively →