MAT1A

Across TCGA patient cohorts, MAT1A mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAT1A-associated genes across cancer lineages are 4E-BP1, C-Raf, and EGFR_pY1068. Each is linked with MAT1A in more than 1 cancer types. Because this analysis shows association rather than direction, both MAT1A-to-partner and partner-to-MAT1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MAT1A-low versus MAT1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAT1A→partner) and Y-score (partner→MAT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.353	+2.936	<.001	<.001	3	2
UCEC	C-Raf →	+0.175	+2.415	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.209	-1.662	.018	.011	3	2
UCEC	A-Raf_pS299 →	-0.115	-1.662	.006	.011	3	2
UCEC	Notch1 →	+0.131	+1.662	.008	.011	3	2
UCEC	Shc_pY317 →	-0.135	-3.169	.011	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

4E-BP1 by MAT1A expression — UCEC

Explore this box plot interactively →