MAT1A

Across TCGA cell cohorts, MAT1A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,417 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MAT1A-associated GO terms across cancer lineages are S-adenosylmethionine biosynthetic process, Regulation of postsynaptic specialization assembly, and L-amino acid biosynthetic process. Each is linked with MAT1A in more than 9 cancer types. Because this analysis shows association rather than direction, both MAT1A-to-partner and partner-to-MAT1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S-adenosylmethionine biosynthetic process grouped by MAT1A-low versus MAT1A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAT1A→partner) and Y-score (partner→MAT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	S-adenosylmethionine biosynthetic process →	-0.136	-0.971	<.001	<.001	3	10
KIDNEY	Regulation of postsynaptic specialization assembly →	-0.087	-0.822	<.001	.004	3	6
LIVER	L-amino acid biosynthetic process →	+0.152	+2.149	<.001	.001	3	5
BLOOD_Leukemia	Regulation of ventricular cardiac muscle cell membrane depolarization →	-0.461	-0.343	.002	.002	3	5
SKIN	Cellular response to insulin stimulus →	+0.034	+1.426	.004	.001	3	5
OVARY	L-aspartate biosynthetic process →	+0.111	+1.006	.005	.009	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,417 associations by consensus.

S-adenosylmethionine biosynthetic process by MAT1A expression — LUNG_SCLC

Explore this box plot interactively →