MAT1A

Across TCGA cell cohorts, MAT1A mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAT1A-associated genes across cancer lineages are OR1L6, GYPB, and ETNPPL. Each is linked with MAT1A in more than 1 cancer types. Because this analysis shows association rather than direction, both MAT1A-to-partner and partner-to-MAT1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by MAT1A-low versus MAT1A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAT1A→partner) and Y-score (partner→MAT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1L6 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	GYPB →	+0.182	+4.544	<.001	.003	3	1
LARGE_INTESTINE	ETNPPL →	+0.286	+3.758	<.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.022	+4.614	<.001	.002	3	1
LARGE_INTESTINE	ACSM6 →	+0.019	+3.658	.002	.005	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR1L6 by MAT1A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →