MAST4

Across TCGA patient cohorts, MAST4 mutation is significantly associated with the RNA expression of many other genes, with 7,273 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAST4-associated genes across cancer lineages are PTMAP9, HPGDS, and FCGR3A. Each is linked with MAST4 in more than 4 cancer types. Because this analysis shows association rather than direction, both MAST4-to-partner and partner-to-MAST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTMAP9 grouped by MAST4-low versus MAST4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAST4→partner) and Y-score (partner→MAST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PTMAP9 →	+0.649	+2.700	<.001	.006	3	5
UCEC	HPGDS →	-0.336	-1.391	<.001	.001	3	5
UCEC	FCGR3A →	+1.204	+1.862	<.001	<.001	3	4
UCEC	SLC25A39 →	+0.260	+1.743	.001	<.001	3	4
STAD	PTGER1 →	-1.078	-2.683	.001	.006	3	4
UCEC	CCNB1 →	+0.767	+2.222	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,273 associations by consensus.

PTMAP9 by MAST4 expression — STAD

Explore this box plot interactively →