MAST4

Across TCGA patient cohorts, MAST4 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAST4-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and ATM. Each is linked with MAST4 in more than 4 cancer types. Because this analysis shows association rather than direction, both MAST4-to-partner and partner-to-MAST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAST4-low versus MAST4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAST4→partner) and Y-score (partner→MAST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.470	+3.476	<.001	.002	3	5
STAD	ASNS →	+0.391	+3.321	.042	.009	3	4
COAD	ATM →	-0.498	-2.321	.001	.033	3	4
STAD	TFRC →	+0.613	+3.000	.023	.034	3	3
UCEC	C-Raf →	+0.141	+1.353	<.001	.013	3	3
UCEC	eEF2 →	+0.288	+1.169	.005	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Caspase-7-cleavedD198 by MAST4 expression — COAD

Explore this box plot interactively →