MAST4

Across TCGA cell cohorts, MAST4 mutation is significantly associated with the RNA expression of many other genes, with 1,302 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAST4-associated genes across cancer lineages are ACBD5, TOMM20L, and MIOX. Each is linked with MAST4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAST4-to-partner and partner-to-MAST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACBD5 grouped by MAST4-low versus MAST4-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAST4→partner) and Y-score (partner→MAST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ACBD5 →	+0.723	+3.000	.001	.003	3	3
SKIN	TOMM20L →	+0.094	+2.628	.002	.002	3	2
BLOOD_Leukemia	MIOX →	+0.238	+2.629	.008	.004	3	2
LARGE_INTESTINE	PMM1 →	+0.501	+2.700	.003	.001	3	2
LARGE_INTESTINE	DDHD1 →	+0.620	+2.043	.002	.001	3	2
LARGE_INTESTINE	DNASE2 →	+0.669	+1.628	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,302 associations by consensus.

ACBD5 by MAST4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →