MAST4-IT1

Across TCGA pan-cancer cohorts, MAST4-IT1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated MAST4-IT1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MAST4-IT1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MAST4-IT1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and ESCA show a favorable association.

LUAD, READ, and UCEC are the cancer types where MAST4-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.933	0.763	<.001	102	view →
READ	DFS	Tertile	II,III,IV	0.059	0.818	<.001	54	view →
UCEC	OS	Tertile	IV	0.066	0.755	<.001	54	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	42	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	27	view →
ACC	OS	Tertile	II,III,IV	0.135	0.658	.010	27	view →
BRCA	DFS	Tertile	III,IV	0.962	0.857	.018	18	view →
BLCA	OS	Tertile	IV	0.182	0.489	.013	18	view →
TGCT	DFS	Tertile	All	0.392	0.806	.008	18	view →
LIHC	OS	Tertile	III,IV	0.158	0.623	<.001	18	view →
HNSC	DFS	Tertile	IV	0.288	0.590	.036	12	view →
MESO	OS	Tertile	All	0.588	0.352	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

MAST4-IT1–LUAD (DFS)

Open the LUAD breakdown →