MAST3

Across TCGA patient cohorts, MAST3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAST3-associated genes across cancer lineages are ATM, ERCC1, and GAPDH. Each is linked with MAST3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAST3-to-partner and partner-to-MAST3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MAST3-low versus MAST3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAST3→partner) and Y-score (partner→MAST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.782	-2.536	<.001	<.001	3	3
COAD	ERCC1 →	+0.230	+2.840	.001	.033	3	2
UCEC	GAPDH →	+0.504	+2.415	.002	.002	3	2
COAD	PARP_cleaved →	+0.592	+3.000	.008	.034	3	2
COAD	SETD2 →	+0.415	+3.012	.015	.018	3	2
COAD	Caspase-7-cleavedD198 →	+1.113	+3.186	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ATM by MAST3 expression — UCEC

Explore this box plot interactively →