MAST3

Across TCGA cell cohorts, MAST3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,227 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MAST3-associated GO terms across cancer lineages are Positive regulation of T-helper 17 cell lineage commitment, Positive regulation of cell fate commitment, and Positive regulation of intracellular estrogen receptor signaling pathway. Each is linked with MAST3 in more than 12 cancer types. Because this analysis shows association rather than direction, both MAST3-to-partner and partner-to-MAST3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of T-helper 17 cell lineage commitment grouped by MAST3-low versus MAST3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAST3→partner) and Y-score (partner→MAST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of T-helper 17 cell lineage commitment →	+0.227	+1.067	.003	<.001	3	13
LUNG_SCLC	Positive regulation of cell fate commitment →	+0.204	+0.886	.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.172	+0.687	<.001	<.001	3	12
STOMACH	Positive regulation of double-strand break repair →	+0.065	+0.648	.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.078	+0.645	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.087	+0.568	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,227 associations by consensus.

Positive regulation of T-helper 17 cell lineage commitment by MAST3 expression — STOMACH

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