MAST3

Across TCGA cell cohorts, MAST3 mutation is significantly associated with the RNA expression of many other genes, with 220 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAST3-associated genes across cancer lineages are CDT1, PAX4, and SLC17A1. Each is linked with MAST3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAST3-to-partner and partner-to-MAST3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDT1 grouped by MAST3-low versus MAST3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAST3→partner) and Y-score (partner→MAST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDT1 →	+0.759	+3.366	.001	.002	3	2
SOFT_TISSUE	PAX4 →	+0.015	+4.930	.002	.008	3	1
SOFT_TISSUE	SLC17A1 →	+1.392	+4.930	<.001	.008	3	1
CNS	OR1J1 →	+0.103	+3.363	.001	.006	3	1
CNS	PRSS41 →	+0.015	+3.058	.004	.002	3	1
BREAST	DEFA4 →	+0.035	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 220 associations by consensus.

CDT1 by MAST3 expression — BLOOD_Leukemia

Explore this box plot interactively →