MAST2

Across TCGA patient cohorts, MAST2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAST2-associated genes across cancer lineages are ATM, INPP4B, and PDK1_pS241. Each is linked with MAST2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAST2-to-partner and partner-to-MAST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MAST2-low versus MAST2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAST2→partner) and Y-score (partner→MAST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.640	-1.999	<.001	<.001	3	3
COAD	INPP4B →	-0.490	-3.169	.002	.017	3	2
COAD	PDK1_pS241 →	-0.155	-2.987	.033	.035	3	2
COAD	TAZ →	+0.207	+2.832	.015	.034	3	2
UCEC	eEF2 →	+0.236	+1.584	.029	.032	3	2
UCEC	eIF4E →	+0.196	+1.999	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ATM by MAST2 expression — UCEC

Explore this box plot interactively →