MAST2

Across TCGA cell cohorts, MAST2 mutation is significantly associated with the RNA expression of many other genes, with 586 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAST2-associated genes across cancer lineages are FMO1, BCL7A, and PPIAL4F. Each is linked with MAST2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAST2-to-partner and partner-to-MAST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMO1 grouped by MAST2-low versus MAST2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAST2→partner) and Y-score (partner→MAST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FMO1 →	+0.077	+2.185	.001	.001	3	3
LARGE_INTESTINE	BCL7A →	+0.768	+3.169	.002	.009	3	3
KIDNEY	PPIAL4F →	+0.133	+4.121	<.001	.006	3	2
CNS	SIGLEC14 →	+0.055	+2.611	.004	.009	3	2
LARGE_INTESTINE	DEPDC5 →	+0.536	+3.321	.003	.003	3	2
LARGE_INTESTINE	R3HCC1 →	+0.862	+3.743	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 586 associations by consensus.

FMO1 by MAST2 expression — LARGE_INTESTINE

Explore this box plot interactively →