MASP2

Across TCGA patient cohorts, MASP2 protein abundance is significantly associated with the RNA expression of many other genes, with 7,520 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MASP2-associated genes across cancer lineages are LYVE1, ZFP36, and MAFF. Each is linked with MASP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MASP2-to-partner and partner-to-MASP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MASP2 versus LYVE1 in GBM, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASP2→partner) and Y-score (partner→MASP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LYVE1 →	+1.930	+0.685	<.001	.006	3	5
OV	ZFP36 →	+1.500	+0.687	<.001	<.001	3	4
OV	MAFF →	+0.900	+0.661	.003	.008	3	4
CCRCC	DCN →	+2.011	+0.799	<.001	<.001	3	4
COAD	POSTN →	+1.686	+0.520	.001	<.001	3	4
UCEC	ENPEP →	+1.220	+0.903	.003	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,520 associations by consensus.

MASP2 vs LYVE1 — GBM

Explore this scatter interactively →