MASP2

Across TCGA patient cohorts, MASP2 mutation is significantly associated with the RNA expression of many other genes, with 2,301 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MASP2-associated genes across cancer lineages are C4orf46, SNORD90, and RPL17P50. Each is linked with MASP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MASP2-to-partner and partner-to-MASP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf46 grouped by MASP2-low versus MASP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASP2→partner) and Y-score (partner→MASP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C4orf46 →	+0.440	+2.201	.001	.001	3	3
UCEC	SNORD90 →	+0.182	+1.471	.001	.008	3	3
UCEC	RPL17P50 →	+0.316	+1.679	.006	.006	3	3
UCEC	HROB →	+0.450	+2.673	.001	<.001	3	3
UCEC	ATP1B2 →	-0.640	-1.773	<.001	<.001	3	3
UCEC	DDIT4 →	+0.727	+1.593	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,301 associations by consensus.

C4orf46 by MASP2 expression — UCEC

Explore this box plot interactively →