MASP2

Across TCGA patient cohorts, MASP2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MASP2-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, STAT3_pY705, and eIF4E. Each is linked with MASP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MASP2-to-partner and partner-to-MASP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by MASP2-low versus MASP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASP2→partner) and Y-score (partner→MASP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.422	+1.857	.009	.004	3	2
UCEC	STAT3_pY705 →	-0.308	-1.289	<.001	.023	3	2
UCEC	eIF4E →	+0.214	+2.058	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.155	-2.662	<.001	<.001	3	1
UCEC	ERK2 →	+0.199	+1.765	.001	.013	3	1
UCEC	FOXO3a_pS318_S321 →	-0.083	-1.289	.037	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Acetyl-a-Tubulin-Lys40 by MASP2 expression — UCEC

Explore this box plot interactively →