MASP2

Across TCGA cell cohorts, MASP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,421 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MASP2-associated GO terms across cancer lineages are Regulation of telomerase RNA localization to Cajal body, Host-mediated perturbation of viral process, and Promoter clearance during DNA-templated transcription. Each is linked with MASP2 in more than 16 cancer types. Because this analysis shows association rather than direction, both MASP2-to-partner and partner-to-MASP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomerase RNA localization to Cajal body grouped by MASP2-low versus MASP2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MASP2→partner) and Y-score (partner→MASP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of telomerase RNA localization to Cajal body →	+0.111	+0.873	<.001	<.001	3	17
LARGE_INTESTINE	Host-mediated perturbation of viral process →	+0.083	+0.610	<.001	<.001	3	17
LARGE_INTESTINE	Promoter clearance during DNA-templated transcription →	+0.131	+0.692	<.001	<.001	3	16
LARGE_INTESTINE	RNA polymerase II promoter clearance →	+0.131	+0.692	<.001	<.001	3	16
BONE	Regulation of mRNA splicing, via spliceosome →	+0.090	+0.879	<.001	.001	3	16
BONE	Positive regulation of DNA metabolic process →	+0.081	+0.850	.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,421 associations by consensus.

Regulation of telomerase RNA localization to Cajal body by MASP2 expression — BONE

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