MASP1

Across TCGA pan-cancer cohorts, MASP1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MASP1 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher MASP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MASP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SCLC, OV, and COAD are the cancer types where MASP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.082	0.648	<.001	18	view →
OV	OS	Median	IV	0.007	0.760	<.001	12	view →
COAD	OS	Median	IV	0.082	0.659	<.001	12	view →
MESO	OS	Median	II,III,IV	0.121	0.571	.004	9	view →
SARC	DFS	Median	All	0.179	0.594	.031	6	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →
BLCA	DFS	Median	IV	0.139	0.483	.002	6	view →
UCEC	DFS	Median	All	0.916	0.613	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MASP1–SCLC (OS)

Open the SCLC breakdown →