MASP1

Across TCGA pan-cancer cohorts, MASP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MASP1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MASP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MASP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where MASP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.249	0.797	.001	32	view →
CCRCC	OS	Median	All	1.000	0.906	.016	12	view →
PDAC	OS	Tertile	II,III,IV	0.671	0.968	.006	12	view →
LSCC	DFS	Quartile	II,III,IV	0.823	1.000	.014	6	view →
GBM	DFS	Median	All	0.447	0.293	.021	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MASP1–LUAD (DFS)

Open the LUAD breakdown →