MASP1

Across TCGA patient cohorts, MASP1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,817 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MASP1-associated genes across cancer lineages are IL6, DIPK2B, and SOCS3. Each is linked with MASP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MASP1-to-partner and partner-to-MASP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MASP1 versus IL6 in PDAC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASP1→partner) and Y-score (partner→MASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IL6 →	+1.486	+0.650	<.001	<.001	3	6
BRCA	DIPK2B →	+0.889	+0.553	<.001	<.001	3	6
LUAD	SOCS3 →	+1.059	+0.419	<.001	<.001	3	6
BRCA	MYCT1 →	+0.867	+0.485	<.001	<.001	3	6
BRCA	BCL6B →	+0.703	+0.456	<.001	.001	3	6
HNSC	VEGFC →	+1.200	+0.460	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,817 associations by consensus.

MASP1 vs IL6 — PDAC

Explore this scatter interactively →