MASP1

Across TCGA patient cohorts, MASP1 mutation is significantly associated with the RNA expression of many other genes, with 5,679 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MASP1-associated genes across cancer lineages are C5orf22, NCAPG, and COX5A. Each is linked with MASP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MASP1-to-partner and partner-to-MASP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf22 grouped by MASP1-low versus MASP1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASP1→partner) and Y-score (partner→MASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	C5orf22 →	+0.512	+3.744	.001	<.001	3	5
UCEC	NCAPG →	+0.693	+1.635	<.001	<.001	3	5
COAD	COX5A →	+0.435	+2.741	<.001	.002	3	5
COAD	REXO5 →	+0.378	+1.926	.002	.008	3	5
UCEC	TIPIN →	+0.496	+2.606	<.001	<.001	3	5
LUAD	RRM2 →	+0.997	+3.205	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,679 associations by consensus.

C5orf22 by MASP1 expression — LUAD

Explore this box plot interactively →