MASP1

Across TCGA patient cohorts, MASP1 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MASP1-associated genes across cancer lineages are Caspase-7-cleavedD198, PDCD4, and 4E-BP1. Each is linked with MASP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MASP1-to-partner and partner-to-MASP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MASP1-low versus MASP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MASP1→partner) and Y-score (partner→MASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.603	+1.479	<.001	.006	3	4
LUAD	PDCD4 →	-0.382	-3.169	.034	.018	3	3
UCEC	4E-BP1 →	+0.326	+2.280	<.001	<.001	3	3
UCEC	Di-Ras3 →	-0.145	-1.830	<.001	<.001	3	3
UCEC	eEF2 →	+0.229	+1.415	.022	.040	3	3
UCEC	ACC1 →	+0.370	+2.083	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Caspase-7-cleavedD198 by MASP1 expression — UCEC

Explore this box plot interactively →