MASP1

Across TCGA cell cohorts, MASP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,652 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MASP1-associated GO terms across cancer lineages are Protein exit from endoplasmic reticulum, ERAD pathway, and Endoplasmic reticulum to cytosol transport. Each is linked with MASP1 in more than 7 cancer types. Because this analysis shows association rather than direction, both MASP1-to-partner and partner-to-MASP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein exit from endoplasmic reticulum grouped by MASP1-low versus MASP1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MASP1→partner) and Y-score (partner→MASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein exit from endoplasmic reticulum →	+0.139	+0.198	<.001	.001	3	8
BLOOD_Lymphoma	ERAD pathway →	+0.051	+0.129	<.001	.003	2	8
LUNG_NSCLC_LUSC	Endoplasmic reticulum to cytosol transport →	+0.137	+0.231	.003	.003	3	6
LUNG_NSCLC_LUSC	Retrograde protein transport, ER to cytosol →	+0.137	+0.231	.003	.003	3	6
LARGE_INTESTINE	Regulation of macroautophagy →	+0.046	+0.132	<.001	.007	3	6
BLOOD_Lymphoma	Regulation of response to endoplasmic reticulum stress →	+0.061	+0.149	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,652 associations by consensus.

Protein exit from endoplasmic reticulum by MASP1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →