MARVELD3

Across TCGA pan-cancer cohorts, MARVELD3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MARVELD3 data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MARVELD3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MARVELD3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, COAD, and PDAC are the cancer types where MARVELD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.281	0.719	.001	38	view →
COAD	DFS	Median	All	0.898	1.000	.037	12	view →
PDAC	DFS	Tertile	III,IV	0.441	0.977	.006	10	view →
CCRCC	DFS	Tertile	All	1.000	0.909	.043	3	view →
LSCC	DFS	Quartile	II,III,IV	0.172	0.767	.038	3	view →
HNSC	DFS	Median	IV	0.802	0.548	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MARVELD3–LUAD (DFS)

Open the LUAD breakdown →